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Dr. Wishnev, I reached out to the Lynch Syndrome Screening Network about your query related to CDH1 and CRC association, and there is some very slowly expanding evidence of potential increased risk for colorectal neoplasia with this mutation, but as ...

This is a tricky question, and I am curious what you do and what other perspective is offered. I have not found any specific recommendations for prophylactic colectomy for CDH1 either, including not in the NCCN guidelines. Given that she is facing (hopefully ...

I have a 53 yo black female with an upper rectal/rectosigmoid tumor. She has been found to have a deleterious mutation in CDH1. She has not had an EGD yet. I can't seem to find any recommendations regarding total or subtotal colectomy vs close surveillance ...